The match at the Etihad Stadium in Manchester, United Kingdom, kicks off at 4:30pm (15:30 GMT).
Ten-time English champions City are six points behind Arsenal but have a game in hand.
Arsenal, aiming for their first league title since 2004, were in contention for four titles until last month but are now scrambling to maintain their lead in the league and have stumbled into the Champions League semifinals.
Pep Guardiola’s City can pile the pressure on Arsenal with a win today and in their midweek match against Burnley, with a chance to go level on points before Arsenal’s next league game.
Mikel Arteta’s Arsenal will host Newcastle United in their next game on Saturday.
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